Aspirin → 2-Acetoxybenzoyl chloride
Reaction equation
[C:1]([O:4][C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7](O)=[O:8])(=[O:3])[CH3:2].C(Cl)(C([Cl:18])=O)=O>C1COCC1>[C:1]([O:4][C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7]([Cl:18])=[O:8])(=[O:3])[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of compound 2-acetoxybenzoic acid (1.0 g, 5.5 mmol) in THF (30 mL) was added (COCl)2 (0.8 mL, 9.1 mmol) at 0° C. The mixture was heated (reflux, 1.5 h) and concentrated under reduced pressure to afford 2-(chlorocarbonyl)-phenyl acetate.
Workup
- temperatureThe mixture was heated
- temperature(reflux, 1.5 h)
- concentrationconcentrated under reduced pressure
Sources & evidence
- ORD record
- ord-ffa9aee03798440c969400fefb0bae74
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08846972B2
Reaction notes
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