Hydrochloric Acid → Ethyl 2-cyanobenzimidate hydrochloride
Reaction equation
[C:1](#[N:10])[C:2]1[C:3](=[CH:6][CH:7]=[CH:8][CH:9]=1)[C:4]#[N:5].[ClH:11].[CH2:12]([OH:14])[CH3:13]>C(Cl)(Cl)Cl>[ClH:11].[CH2:12]([O:14][C:1](=[NH:10])[C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5])[CH3:13]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
A suspension of phthalonitrile (70 g, 0.55 mol) in ethanol (100 ml) and chloroform (200 ml) was warmed and then cooled to 0° C. The reaction mixture was saturated with HCl (g) and then aged at 0° C. for 2 weeks. The resultant precipitate was filtered and washed with chloroform. Dilution of the filtrate with ether produced additional 2-cyano-benzimidic acid ethyl ester hydrochloride.
Workup
- temperaturewas warmed
- waitaged at 0° C. for 2 weeks
- filtrationThe resultant precipitate was filtered
- washwashed with chloroform
Sources & evidence
- ORD record
- ord-36061fadbe454fa5bf14e7a2c5253b4f
- Source dataset
- uspto-grants-2006_12
- Patent number
- US07144899B2
Reaction notes
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