Benzaldehyde → HCID 178419005, compound

HRID 860107

Reaction equation

HRID 860107 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[C:8]([N+:12]#[C-:13])([CH3:11])([CH3:10])[CH3:9].[CH:14](=O)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[C:22]([Cl:25])(=[O:24])[CH3:23]>Cl(O)(=O)(=O)=O>[Cl-:25].[C:22]([N+:1]1[C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:13]([NH:12][C:8]([CH3:11])([CH3:10])[CH3:9])[N:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=12)(=[O:24])[CH3:23]

Participants

6

Reactant 4

HCID 240BenzaldehydeHCID 6367Acetyl chlorideHCID 104392-AminopyridineHCID 23577Tert-Butyl isocyanide

Product 1

HCID 178419005HCID 178419005, compound

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Example 1 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2-amino-pyridine (0.1 M, DCM), 0.575 ml (0.115 mmol) tert.-butylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) benzaldehyde solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

Sources & evidence

ORD record
ord-e8c0457d86b043a4a3e777f1ec561d09
Source dataset
uspto-grants-2006_12
Patent number
US07153873B2

Linked notes

Loading…