Benzaldehyde → HCID 178418850, compound

HRID 860112

Reaction equation

HRID 860112 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH:8]1([N+:14]#[C-:15])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.[CH:16](=O)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[C:24]([Cl:27])(=[O:26])[CH3:25]>Cl(O)(=O)(=O)=O>[Cl-:27].[C:24]([N+:1]1[C:16]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:15]([NH:14][CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)[N:3]2[CH:4]=[CH:5][CH:6]=[N:7][C:2]=12)(=[O:26])[CH3:25]

Participants

6

Reactant 4

HCID 240BenzaldehydeHCID 6367Acetyl chlorideHCID 79782-AminopyrimidineHCID 79129Cyclohexyl isocyanide

Product 1

HCID 178418850HCID 178418850, compound

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Example 6 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2-amino-pyrimidine (0.1 M, DCM), 0.575 ml (0.115 mmol) cyclohexylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) benzaldehyde solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

Sources & evidence

ORD record
ord-5a3f58d8d6c543708c83bb8200d6c370
Source dataset
uspto-grants-2006_12
Patent number
US07153873B2

Linked notes

Loading…