Potassium Carbonate → HCID 69019515, compound

HRID 860784

Reaction equation

HRID 860784 reaction equation
C([O-])([O-])=O.[K+].[K+].[NH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2([C:19]3[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=3)[O:18][CH2:17][CH2:16][O:15]2)=[CH:10][C:9]=1[CH:26]([C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[CH:29]=1)[OH:27].[Br:35][CH2:36][C:37](Br)=[O:38]>C(Cl)Cl>[Br:35][CH2:36][C:37]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2([C:19]3[CH:20]=[CH:21][C:22]([Cl:25])=[CH:23][CH:24]=3)[O:18][CH2:17][CH2:16][O:15]2)=[CH:10][C:9]=1[CH:26]([C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[CH:29]=1)[OH:27])=[O:38]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 61147Bromoacetyl bromideHCID 690198082-Amino-alpha-(3-chlorophenyl)-5-[2-(4-chlorophenyl)-1,3-dioxolan-2-yl]-benzenemethanol

Product 1

HCID 69019515HCID 69019515, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

K2CO3 10% (250 ml) was added to a mixture of intermediate (9) (0.072 mol) in DCM (250 ml). Then bromo-acetyl bromide (0.072 mol) was added dropwise at room temperature. The mixture was stirred at room temperature overnight. The organic layer was separated, dried (MgSO4), filtered and the solvent was evaporated till dryness. The product was used without further purification, yielding (quant.) of 2-bromo-N-[4-[2-(4-chlorophenyl)-1,3-dioxolan-2-yl]-2-[(3-chlorophenyl)hydroxymethyl]phenyl]-acetamide (intermediate 10).

Workup

  1. customThe organic layer was separated
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. customthe solvent was evaporated till dryness
  5. customThe product was used without further purification

Sources & evidence

ORD record
ord-53f0595b634948e0813ef477d7935be0
Source dataset
uspto-grants-2006_12
Patent number
US07153958B2

Linked notes

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