Oxalyl chloride → 4-[(4-Pyridyl)piperazin-1-yl]benzoyl chloride

HRID 864797

Reaction equation

HRID 864797 reaction equation
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[N:7]1[CH:12]=[CH:11][C:10]([CH:13]2[CH2:18][NH:17][CH2:16][CH2:15][N:14]2[C:19]2[CH:27]=[CH:26]C(C(O)=O)=[CH:21][CH:20]=2)=[CH:9][CH:8]=1>ClCCl.CN(C=O)C>[N:7]1[CH:8]=[CH:9][C:10]([CH:13]2[CH2:18][NH:17][CH2:16][CH2:15][N:14]2[C:19]2[CH:27]=[CH:26][C:1]([C:2]([Cl:4])=[O:3])=[CH:21][CH:20]=2)=[CH:11][CH:12]=1

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 189183004-((4-Pyridyl)piperazin-1-yl)benzoic acid

Product 1

HCID 189183644-[(4-Pyridyl)piperazin-1-yl]benzoyl chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

Oxalyl chloride (0.5 ml) was added to a stirred suspension of 4-((4-pyridyl)piperazin-1-yl)benzoic acid in dichloromethane (15 ml), followed by DMF (1 drop). The mixture was stirred for 2 hours and evaporated to dryness to give 4-[(4-pyridyl)piperazin-1-yl]benzoyl chloride which was used immediately.

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-836c7a8d52cf4ae0bbbea4732fad7ac9
Source dataset
uspto-grants-1996_10
Patent number
US05563141

Linked notes

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