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Diisopropylethylamine → HCID 58911823, compound

HRID 874161
Notes
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Reaction equation

HRID 874161 reaction equation
Cl.[NH2:2][CH:3]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:4]#[N:5].[C:12]([N:29]=[C:30]=[S:31])([O:14][CH2:15][CH:16]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[C:22]2[C:17]1=[CH:18][CH:19]=[CH:20][CH:21]=2)=[O:13].C(N(C(C)C)C(C)C)C.C(=O)(O)[O-].[Na+]>C(Cl)Cl>[NH2:5][C:4]1[S:31][C:30]([NH:29][C:12]([O:14][CH2:15][CH:16]2[C:17]3[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:23]3[C:28]2=[CH:27][CH:26]=[CH:25][CH:24]=3)=[O:13])=[N:2][C:3]=1[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 81531DiisopropylethylamineHCID 516892Sodium BicarbonateHCID 27237172-Phenylglycinonitrile hydrochlorideHCID 4154759Fmoc isothiocyanate

Product 1

HCID 58911823HCID 58911823, compoundYield 48%

Reagents, catalysts & solvents 1

HCID 6344
Dichloromethane
Solvent

Procedure

A suspension of α-aminophenylacetonitrile hydrochloride (3.19 g, 18.9 mmol) and Fmoc-isothiocyanate (5.31 g, 18.9 mmol) in DCM was treated with ethyldiisopropylamine (3.62 ml, 20.8 mmol) at 0° C. for 1 hr and then at ambient temperature for 3 hr. The mixture was poured into saturated aqueous sodium bicarbonate and extracted three times into ethyl acetate. The combined organic phases were washed with water and brine, and dried over sodium sulfate and concentrated in vacuo. Flash chromatography on silica gel (ethyl acetate/hexanes) yielded 5-amino-2-(Fmoc-amino)-4-phenylthiazole (3.75 g, 48%).

Workup

  1. extractionextracted three times into ethyl acetate
  2. washThe combined organic phases were washed with water and brine
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-16dfd202abc746b7af69108257c630ce
Source dataset
uspto-grants-2015_03
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08980837B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes