Water → HCID 178446233, compound

HRID 882879

Reaction equation

HRID 882879 reaction equation
Br[C:2]1[N:10]([CH2:11][CH:12]=[C:13]([CH3:15])[CH3:14])[C:9]2[C:8](=[O:16])[N:7]([CH2:17][C:18](=[O:25])[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:6](=[O:26])[N:5]([CH3:27])[C:4]=2[N:3]=1.Cl.COC(=O)[C@H](C[SH:35])N.C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O.C(O)(=O)C>[SH:35][C:2]1[N:10]([CH2:11][CH:12]=[C:13]([CH3:15])[CH3:14])[C:9]2[C:8](=[O:16])[N:7]([CH2:17][C:18](=[O:25])[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:6](=[O:26])[N:5]([CH3:27])[C:4]=2[N:3]=1

Participants

7

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 2733208L-Cysteine, methyl ester, hydrochlorideHCID 247501618-Bromo-3-methyl-7-(3-methylbut-2-enyl)-1-(2-oxo-2-phenylethyl)-3,7-dihydropurine-2,6-dione

Product 1

HCID 178446233HCID 178446233, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
90 °C

Procedure

50 mg of 8-bromo-3-methyl-7-(3-methylbut-2-enyl)-1-(2-oxo-2-phenylethyl) -3,7-dihydropurine-2,6-dione were dissolved in 1 ml of dimethylformamide and, after addition of 24 mg of L-cysteine methyl ester hydrochloride and 37 mg of potassium carbonate, the mixture was heated with stirring at 90° C. for 1 hour. After cooling to room temperature, 10 ml of water were added, and the mixture was made weakly acidic with glacial acetic acid. A precipitate separated out on stirring and was filtered off and dried in a vacuum.

Workup

  1. temperaturethe mixture was heated
  2. temperatureAfter cooling to room temperature
  3. customA precipitate separated out
  4. stirringon stirring
  5. filtrationwas filtered off
  6. customdried in a vacuum

Sources & evidence

ORD record
ord-9d0c5bf723fb46f7bf841c35f2ce46e4
Source dataset
uspto-grants-2012_08
Patent number
US08236810B2

Linked notes

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