Boron trifluoride etherate → Daidzein

HRID 884733

Reaction equation

HRID 884733 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:18])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1.B(F)(F)F.[CH3:23]COCC.CS(Cl)(=O)=O>CN(C=O)C>[OH:8][C:6]1[CH:7]=[C:2]2[C:3]([C:9](=[O:18])[C:10]([C:11]3[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=3)=[CH:23][O:1]2)=[CH:4][CH:5]=1

Participants

5

Reactant 3

HCID 8000Boron trifluoride etherateHCID 31297Methanesulfonyl chlorideHCID 6400962,4,4'-Trihydroxydeoxybenzoin

Product 1

HCID 5281708Daidzein

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Conditions

Temperature
50 °C

Procedure

In a solution of 1-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)-ethanone (2 mmol) in DMF (6 mL), freshly destilled BF3.OEt2 (6.3 mL) was added under argon. The mixture was heated at 50° C., and a solution of methanesulphonyl chloride (1 mL) in dry DMF (1.5 mL) was added slowly. After reaction at 80° C. for 1 h, the mixture was cooled to rt and poured into a large volume of ice cold aq. sodium acetate (12 g/100 mL), then extracted with EtOAc, and the organic layer was dried and concentrated. The residue was purified by column chromatography on silica gel using a mixture of DCM and MeOH to give 7-hydroxy-3-(4-hydroxyphenyl)-chromen-4-one.

Workup

  1. customAfter reaction at 80° C. for 1 h
  2. temperaturethe mixture was cooled to rt
  3. extractionextracted with EtOAc
  4. customthe organic layer was dried
  5. concentrationconcentrated
  6. customThe residue was purified by column chromatography on silica gel using
  7. additiona mixture of DCM and MeOH

Sources & evidence

ORD record
ord-a49de2df1a8541368fd5a62faf6e5b39
Source dataset
uspto-grants-2012_08
Patent number
US08242130B2

Linked notes

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