HCID 136346349, compound → HCID 136346348, compound
Reaction equation
[O:1]=[C:2]1[C:8]2[N:9]([CH2:15][C:16]3[CH:37]=[CH:36][C:19]4/[C:20](=[CH:29]/[C:30]5[NH:34][C:33](=[O:35])[O:32][N:31]=5)/[C:21]5[CH:28]=[CH:27][CH:26]=[CH:25][C:22]=5[CH2:23][CH2:24][C:18]=4[CH:17]=3)[C:10]([CH2:12][CH2:13][CH3:14])=[N:11][C:7]=2[CH:6]=[CH:5][CH:4]=[CH:3]1>C1COCC1.[Pt](=O)=O>[O:1]=[C:2]1[C:8]2[N:9]([CH2:15][C:16]3[CH:37]=[CH:36][C:19]4/[C:20](=[CH:29]/[C:30]5[NH:34][C:33](=[O:35])[O:32][N:31]=5)/[C:21]5[CH:28]=[CH:27][CH:26]=[CH:25][C:22]=5[CH2:23][CH2:24][C:18]=4[CH:17]=3)[C:10]([CH2:12][CH2:13][CH3:14])=[N:11][C:7]=2[CH2:6][CH2:5][CH2:4][CH2:3]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
Compound 39 (50 mg, 0.1 mmol) obtained in Example 39 was dissolved in THF (1 mL), and platinum (IV) oxide (23 mg, 0.1 mmol) was added under nitrogen atmosphere. Under hydrogen atmosphere, the mixture was stirred at room temperature for 7 hr. The mixture was filtrated, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by preparative thin layer chromatography (hexane/ethyl acetate=1/4) to give the title compound (compound 41, 12 mg, 24%).