Hydrochloric Acid → 5-(4-chlorophenyl)furan-2-carbonyl Chloride
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([C:13]([OH:15])=O)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.O=S(Cl)[Cl:18].Cl>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([C:13]([Cl:18])=[O:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1Participants
4
Procedure
A mixture of 56 g. (0.25 mole) of 5-(p-chlorophenyl)-2-furoic acid and 100 ml. of SOCl2 is refluxed for 31/2 hours so that HCl gas evolves and there is dissolution. The SOCl2 is removed on a rotary evaporator. Benzene is added to the solid residue and is then removed on the rotary evaporator to give 5-(p-chlorophenyl)-2-furoyl chloride.
Workup
- additionA mixture of 56 g
- dissolutiondissolution
- customThe SOCl2 is removed on a rotary evaporator
- additionBenzene is added to the solid residue
- customis then removed on the rotary evaporator
Sources & evidence
- ORD record
- ord-0765c2512ca14c33837126d1b45c10ff
- Source dataset
- uspto-grants-1992_06
- Patent number
- US05118708
Reaction notes
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