Ethyl formate → 5-Hydroxypentylformamide

Temperature

90 °C

2.06 g (20.0 mmol) of 5-amino-1-pentanol was dissolved in 5 mL of ethyl formate and the mixture was stirred at 90° C. for 4 hours. The solvent was distilled off under reduced pressure and the obtained residue was purified by silica gel chromatography (eluting solvent: ethyl acetate/methanol=100/0-70/30) to obtain 1.90 g (yield: 73%) of the title compound as a pale yellow-oil.

1. distillationThe solvent was distilled off under reduced pressure
2. customthe obtained residue was purified by silica gel chromatography (eluting solvent: ethyl acetate/methanol=100/0-70/30)

ORD record

ord-bdeeaed94c8542f988f218988becbf56

Source dataset

uspto-grants-2008_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07365067B2