Triethylamine → 122570-36-9

HRID 903584

Reaction equation

HRID 903584 reaction equation
Cl.[NH2:2][CH2:3][CH2:4][C:5]1[CH:12]=[CH:11][C:9]([OH:10])=[C:7]([OH:8])[CH:6]=1.[C:13]([NH:16][C@H:17]([C:22](O)=[O:23])[CH2:18][CH2:19][S:20][CH3:21])(=[O:15])[CH3:14].C(N(CC)CC)C>CN(C)C=O>[C:13]([NH:16][C@H:17]([C:22]([NH:2][CH2:3][CH2:4][C:5]1[CH:12]=[CH:11][C:9]([OH:10])=[C:7]([OH:8])[CH:6]=1)=[O:23])[CH2:18][CH2:19][S:20][CH3:21])(=[O:15])[CH3:14]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 65340Dopamine HydrochlorideHCID 448580N-acetyl-L-methionine

Product 1

HCID 22812625122570-36-9

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2.85 g of dopamine hydrochloride, 4.32 g of N-hydroxysuccinimide ester of N-acetyl-L-methionine, 3.04 g of triethylamine and 15 ml of dimethylformamide are treated in the same manner as described in Example 5. After the reaction, the mixture is condensed under reduced pressure to remove solvent. The residue is dissolve in ethyl acetate, washed with water and dried. The solution is condensed to remove solvent. 3.1 g of N-(N-acetyl-L-methionyl)-dopamine are obtained as caramel.

Workup

  1. customAfter the reaction
  2. customcondensed under reduced pressure
  3. customto remove solvent
  4. dissolutionThe residue is dissolve in ethyl acetate
  5. washwashed with water
  6. customdried
  7. customcondensed
  8. customto remove solvent

Sources & evidence

ORD record
ord-6823c088a7c342818f6492ad5f3a1b94
Source dataset
uspto-grants-1980_10
Patent number
US04228183

Linked notes

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