Formaldehyde → 1-(6-Bromo-1,3-benzothiazol-2-yl)-3-ethyl-5-methyl-1,3,5-triazinan-2-one

HRID 9144

Reaction equation

HRID 9144 reaction equation
[Br:1][C:2]1[CH:16]=[CH:15][C:5]2[N:6]=[C:7]([NH:9][C:10]([NH:12][CH2:13][CH3:14])=[O:11])[S:8][C:4]=2[CH:3]=1.CN.C=O.[CH3:21][N:22]1[CH2:27]COC[CH2:23]1>O.C(O)C>[Br:1][C:2]1[CH:16]=[CH:15][C:5]2[N:6]=[C:7]([N:9]3[CH2:23][N:22]([CH3:27])[CH2:21][N:12]([CH2:13][CH3:14])[C:10]3=[O:11])[S:8][C:4]=2[CH:3]=1

Participants

7

Reactant 4

HCID 712FormaldehydeHCID 6329MethylamineHCID 79724-MethylmorpholineHCID 219855641-(6-Bromo-2-benzothiazolyl)-3-ethylurea

Product 1

HCID 219855241-(6-Bromo-1,3-benzothiazol-2-yl)-3-ethyl-5-methyl-1,3,5-triazinan-2-oneYield 88%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of 1-(6-bromo-2-benzothiazolyl)-3-ethylurea, methylamine, formaldehyde, and N-methyl morpholine in a mixed solvent of ethanol and water was reacted to give the desired compound 1.56 g (88%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-a17e519171264a8d8ae9d98f193b2ac4
Source dataset
uspto-grants-2006_08
Patent number
US07091227B2

Linked notes

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