Acetonitrile → 2-Amino-3-cyano-5-[(4-trifluoromethylphenyl)ethynyl]pyrazine

HRID 91578

Reaction equation

HRID 91578 reaction equation
[CH3:23][CH2:24][N:25]([CH2:26][CH3:27])[CH2:28][CH3:29].[CH3:30][C:31]#[N:32].[Cu:33]([I:34])[I:35].[F:12][C:13]([c:14]1[cH:15][cH:16][c:17]([I:20])[cH:18][cH:19]1)([F:21])[F:22].[NH2:1][c:2]1[n:3][cH:4][c:5]([C:10]#[CH:11])[n:6][c:7]1[C:8]#[N:9]>>[NH2:1][c:2]1[n:3][cH:4][c:5]([C:10]#[C:11][c:17]2[cH:16][cH:15][c:14]([C:13]([F:12])([F:21])[F:22])[cH:19][cH:18]2)[n:6][c:7]1[C:8]#[N:9]

Participants

6

Reactant 5

HCID 6342AcetonitrileHCID 8471TriethylamineHCID 67993Benzene, 1-iodo-4-(trifluoromethyl)-HCID 83717Copper iodideHCID 153352732-Amino-3-cyano-5-ethynylpyrazine

Product 1

HCID 153352742-Amino-3-cyano-5-[(4-trifluoromethylphenyl)ethynyl]pyrazine

Sources & evidence

ORD record
ord-01c3b4e4088b46ed9a2e1b9a45782805
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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