Tetrahydrofuran → N-(2-amino-5-chloropyridin-3-yl)-2,2,2-trifluoroacetamide

HRID 91654

Reaction equation

[CH3:10][CH2:11][N:12]([CH2:13][CH3:14])[CH2:15][CH3:16].[Cl:1][c:2]1[cH:3][c:4]([NH2:9])[c:5]([NH2:8])[n:6][cH:7]1.[F:17][C:18]([F:19])([F:20])[C:21]([Cl:22])=[O:23].[O:24]1[CH2:25][CH2:26][CH2:27][CH2:28]1>>[Cl:1][c:2]1[cH:3][c:4]([NH:9][C:21]([C:18]([F:17])([F:19])[F:20])=[O:23])[c:5]([NH2:8])[n:6][cH:7]1

Participants

Reactant 4

HCID 8028Tetrahydrofuran

HCID 8471Triethylamine

HCID 61106Trifluoroacetyl chloride

HCID 12682545-Chloropyridine-2,3-diamine

Product 1

HCID 130155983N-(2-amino-5-chloropyridin-3-yl)-2,2,2-trifluoroacetamide

Sources & evidence

ORD record: ord-d7a1a0609adc46c8b6ba117747c682ca
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Linked notes

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