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Diisopropylethylamine → 1-Oxa-8-aza-spiro[4.5]decane-8-carboxylic acid (7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-yl)-amide

HRID 917453
Notes
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Reaction equation

HRID 917453 reaction equation
C1(O[C:8](=[O:27])[NH:9][C:10]2[S:11][C:12]3[C:13]([N:21]4[CH2:26][CH2:25][O:24][CH2:23][CH2:22]4)=[N:14][CH:15]=[C:16]([O:19][CH3:20])[C:17]=3[N:18]=2)C=CC=CC=1.FC(F)(F)C(O)=O.[O:35]1[C:39]2([CH2:44][CH2:43][NH:42][CH2:41][CH2:40]2)[CH2:38][CH2:37][CH2:36]1.C(N(CC)C(C)C)(C)C>ClC(Cl)C.O1CCCC1>[CH3:20][O:19][C:16]1[C:17]2[N:18]=[C:10]([NH:9][C:8]([N:42]3[CH2:43][CH2:44][C:39]4([O:35][CH2:36][CH2:37][CH2:38]4)[CH2:40][CH2:41]3)=[O:27])[S:11][C:12]=2[C:13]([N:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)=[N:14][CH:15]=1
ParticipantsProcedureSources & evidenceReaction notes

Participants

6

Reactant 3

HCID 81531DiisopropylethylamineHCID 225077071-Oxa-8-azaspiro[4.5]decane, trifluoroacetate (9CI)HCID 86597258(7-Methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-yl)-carbamic acid phenyl ester

Product 1

HCID 865972741-Oxa-8-aza-spiro[4.5]decane-8-carboxylic acid (7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-yl)-amide

Reagents, catalysts & solvents 2

HCID 6365
1,1-Dichloroethane
Solvent
HCID 8028TetrahydrofuranSolvent

Procedure

From (7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-yl)-carbamic acid phenyl ester with 1-oxa-8-aza-spiro[4.5]decane trifluoroacetate and N,N-diisopropylethylamine in dichloroethane and tetrahydrofuran. ES-MS m/e (%): 434 (M+H+, 100).

Sources & evidence

ORD record
ord-751ab754016f484182b2efc0a72e1686
Source dataset
uspto-grants-2007_09
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07273865B2

Reaction notes

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On this pageParticipantsProcedureSources & evidenceReaction notes