Potassium Carbonate → tert-butyl N-[(1Z,2S)-1-amino-3-cyclopropyl-1-hydroxyiminopropan-2-yl]carbamate

Potassium carbonate (2.18 g, 16 mmol) was dissolved in water (8 mL) and hydroxylamine hydrochloride (1.1 g, 16 mmol) was added. A solution of (S)-tert-butyl 1-cyano-2-cyclopropylethylcarbamate (3.31 g, 16 mmol) in ethanol (24 mL) was added thereto and the resulting reaction mixture was stirred for 72 h. After evaporation of solvents, the residue was dissolved with ethyl acetate (20 mL) and then filtered. The filtrate was concentrated to yield crude product as yellow solid (3.61 g, 94%); MS (EI): m/e 244.2 [M+H]+.

1. customthe resulting reaction mixture
2. customAfter evaporation of solvents
3. dissolutionthe residue was dissolved with ethyl acetate (20 mL)
4. filtrationfiltered
5. concentrationThe filtrate was concentrated

ORD record

ord-a18fa72d740f486aa58238a437e81328

Source dataset

uspto-grants-2016_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09290451B2