[N:1]1([C:6]2[C:7]3[N:8]([C:16]([C:19]([O:21]CC)=[O:20])=[CH:17][N:18]=3)[CH:9]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=2)[CH:5]=[N:4][CH:3]=[N:2]1.C1COCC1.[OH-].[Na+].Cl>O.C(O)C>[N:1]1([C:6]2[C:7]3[N:8]([C:16]([C:19]([OH:21])=[O:20])=[CH:17][N:18]=3)[CH:9]=[C:10]([C:12]([F:14])([F:15])[F:13])[CH:11]=2)[CH:5]=[N:4][CH:3]=[N:2]1
To a mixture of ethyl 8-(1H-1,2,4-triazol-1-yl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylate (320 mg), THF (4 mL) and ethanol (4 mL) was added 2N aqueous sodium hydroxide solution (0.98 mL), and the mixture was stirred at room temperature 3 hr. The reaction mixture was acidified with 1N hydrochloric acid, water was added thereto, and the mixture was extracted with ethyl acetate. The extract was washed successively with water and saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was recrystallized from THF/hexane to give the title compound (270 mg).
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