Tetrahydrofuran → 6-Methyl-2'-[3-(morpholine-4-sulfonyl)-phenyl]-4-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl

Reaction equation

[CH2:34]1[CH2:35][O:36][CH2:37][CH2:38][NH:39]1.[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[CH3:1][c:2]1[cH:3][c:4](-[c:24]2[cH:25][cH:26][c:27]([C:30]([F:31])([F:32])[F:33])[cH:28][cH:29]2)[cH:5][c:6](-[c:8]2[cH:9][c:10](-[c:14]3[cH:15][c:16]([S:20](=[O:21])(=[O:22])[Cl:23])[cH:17][cH:18][cH:19]3)[n:11][cH:12][cH:13]2)[n:7]1.[CH3:45][CH2:46][O:47][C:48]([CH3:49])=[O:50]>>[CH3:1][c:2]1[cH:3][c:4](-[c:24]2[cH:25][cH:26][c:27]([C:30]([F:31])([F:32])[F:33])[cH:28][cH:29]2)[cH:5][c:6](-[c:8]2[cH:9][c:10](-[c:14]3[cH:15][c:16]([S:20](=[O:21])(=[O:22])[N:39]4[CH2:34][CH2:35][O:36][CH2:37][CH2:38]4)[cH:17][cH:18][cH:19]3)[n:11][cH:12][cH:13]2)[n:7]1