Tetrahydrofuran → [2-Oxo4-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-butyl]-phosphonic acid dimethyl ester

Reaction equation

[CH2:13]([O:15][C:16](=[O:14])[CH2:17][CH2:18][c:19]1[n:20][c:21]2[c:26]([cH:27][cH:28]1)[CH2:25][CH2:24][CH2:23][NH:22]2)[CH3:29].[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[CH3:1][P:2]([O:3][CH3:4])([O:5][CH3:6])=[O:7].[CH3:8][CH2:9][CH2:10][CH2:11][Li:12]>>[CH2:1]([P:2]([O:3][CH3:4])([O:5][CH3:6])=[O:7])[C:16](=[O:15])[CH2:17][CH2:18][c:19]1[n:20][c:21]2[c:26]([cH:27][cH:28]1)[CH2:25][CH2:24][CH2:23][NH:22]2