Tetrahydrofuran → tert-butyl 4-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl] phenylaminocarbonyl]piperidine-1-carboxylate

HRID 94088

Reaction equation

HRID 94088 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([C:14](=[O:15])[OH:16])[CH2:12][CH2:13]1.[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH3:42][CH2:43][O:44][C:45](=[O:46])[CH3:47].[F:17][C:18]([c:19]1[n:20][n:21](-[c:28]2[cH:29][cH:30][c:31]([NH2:32])[cH:33][cH:34]2)[c:22]([C:24]([F:25])([F:26])[F:27])[cH:23]1)([F:35])[F:36]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([C:14](=[O:16])[NH:32][c:31]2[cH:30][cH:29][c:28](-[n:21]3[n:20][c:19]([C:18]([F:17])([F:35])[F:36])[cH:23][c:22]3[C:24]([F:25])([F:26])[F:27])[cH:34][cH:33]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 3928711-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acidHCID 27406684-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)aniline

Product 1

HCID 22288408tert-butyl 4-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl] phenylaminocarbonyl]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-95926561848e4b6b9747f9e48e9f7a1d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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