Tetrahydrofuran → 4-(5-chloro-2,4-dimethyl-1H-pyrrol-3-yl)-N-(4-fluorophenyl)pyrimidin-2-amine

Reaction equation

[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[CH3:1][c:2]1[nH:3][cH:4][c:5]([CH3:21])[c:6]1-[c:7]1[n:8][c:9]([NH:13][c:14]2[cH:15][cH:16][c:17]([F:20])[cH:18][cH:19]2)[n:10][cH:11][cH:12]1.[Cl:22][N:23]1[C:24](=[O:25])[CH2:26][CH2:27][C:28]1=[O:29]>>[CH3:1][c:2]1[nH:3][c:4]([Cl:22])[c:5]([CH3:21])[c:6]1-[c:7]1[n:8][c:9]([NH:13][c:14]2[cH:15][cH:16][c:17]([F:20])[cH:18][cH:19]2)[n:10][cH:11][cH:12]1

Participants

Reactant 3

HCID 8028Tetrahydrofuran

HCID 31398Chlorosuccinimide

HCID 9856973[4-(2,4-Dimethyl-1H-pyrrol-3-yl)-pyrimidin-2-yl]-(4-fluoro-phenyl)-amine

Product 1

HCID 65393154-(5-chloro-2,4-dimethyl-1H-pyrrol-3-yl)-N-(4-fluorophenyl)pyrimidin-2-amine

Sources & evidence

ORD record: ord-4cd77c9ebc48437eb13e0bf785d28031
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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