Pyridine → 2-Bromo-4-fluorobenzonitrile

Reaction equation

[Br:1][c:2]1[c:3]([C:4](=[O:5])[NH2:6])[cH:7][cH:8][c:9]([F:11])[cH:10]1.[F:12][C:13]([F:14])([F:15])[C:16]([O:17][C:18](=[O:19])[C:20]([F:21])([F:22])[F:23])=[O:24].[cH:25]1[cH:26][cH:27][n:28][cH:29][cH:30]1>>[Br:1][c:2]1[c:3]([C:4]#[N:6])[cH:7][cH:8][c:9]([F:11])[cH:10]1

Participants

Reactant 3

HCID 1049Pyridine

HCID 9845Trifluoroacetic anhydride

HCID 203722342-Bromo-4-fluorobenzamide

Product 1

HCID 1189392-Bromo-4-fluorobenzonitrile

Sources & evidence

ORD record: ord-2bd58a2a84e44b138bc96451b5461bac
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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