Hydrochloric Acid → 3-[1-(2-hydroxypropyl)piperidin-4-yl]-2H-isoquinolin-1-one

Reaction equation

[Br:19][CH2:20][CH:21]([CH3:22])[OH:23].[ClH:1].[NH:2]1[CH2:3][CH2:4][CH:5]([c:8]2[nH:9][c:10](=[O:18])[c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]3[cH:17]2)[CH2:6][CH2:7]1>>[N:2]1([CH2:20][CH:21]([CH3:22])[OH:23])[CH2:3][CH2:4][CH:5]([c:8]2[nH:9][c:10](=[O:18])[c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]3[cH:17]2)[CH2:6][CH2:7]1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 297401-Bromo-2-propanol

HCID 229311823-(Piperidin-4-yl)-1,2-dihydroisoquinolin-1-one

Product 1

HCID 103341973-[1-(2-hydroxypropyl)piperidin-4-yl]-2H-isoquinolin-1-one

Sources & evidence

ORD record: ord-cb6f105d6b764f8796b2bf343f723e93
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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