Tetrahydrofuran → 2-N-(3-chlorophenyl)-4-N-[(1-methylpyrrolidin-3-yl)methyl]pyrimidine-2,4-diamine

Reaction equation

[Al+3:30].[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[Cl:1][c:2]1[cH:3][c:4]([NH:8][c:9]2[n:10][cH:11][cH:12][c:13]([NH:15][CH2:16][CH:17]3[CH2:18][N:19]([C:22]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:28])[CH2:20][CH2:21]3)[n:14]2)[cH:5][cH:6][cH:7]1.[H-:29].[H-:32].[H-:33].[H-:34].[Li+:31]>>[Cl:1][c:2]1[cH:3][c:4]([NH:8][c:9]2[n:10][cH:11][cH:12][c:13]([NH:15][CH2:16][CH:17]3[CH2:18][N:19]([CH3:22])[CH2:20][CH2:21]3)[n:14]2)[cH:5][cH:6][cH:7]1