Water → 2-Chloro-6-(2,4-difluoro-phenoxy)-quinazoline

HRID 95671

Reaction equation

HRID 95671 reaction equation
[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[Cl:1][c:2]1[n:3][c:4]2[cH:5][cH:6][c:7]([O:13][c:14]3[c:15]([F:21])[cH:16][c:17]([F:20])[cH:18][cH:19]3)[cH:8][c:9]2[c:10]([NH2:12])[n:11]1.[N:22]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:28].[OH2:29]>>[Cl:1][c:2]1[n:3][c:4]2[cH:5][cH:6][c:7]([O:13][c:14]3[c:15]([F:21])[cH:16][c:17]([F:20])[cH:18][cH:19]3)[cH:8][c:9]2[cH:10][n:11]1

Participants

5

Reactant 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 10906Tert-Butyl nitriteHCID 589051302-Chloro-6-(2,4-difluoro-phenoxy)-quinazolin-4-ylamine

Product 1

HCID 589051372-Chloro-6-(2,4-difluoro-phenoxy)-quinazoline

Sources & evidence

ORD record
ord-913b27b9c04b430181522d25f87fdecb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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