Tetrahydrofuran → 3-(2,4-Dichloro-pyrimidin-5-yl)-2-pyridin-4-yl-propionic acid ethyl ester
Reaction equation
[CH2:11]([Li:12])[CH2:13][CH2:14][CH3:15].[CH2:16]([CH3:17])[O:18][C:19]([CH2:20][c:21]1[cH:22][cH:23][n:24][cH:25][cH:26]1)=[O:27].[CH3:43][CH2:44][O:45][C:46](=[O:47])[CH3:48].[CH:1]([NH:2][CH:3]1[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]1)([CH3:9])[CH3:10].[Cl:28][c:29]1[n:30][cH:31][c:32]([CH2:36][I:37])[c:33]([Cl:35])[n:34]1.[O:38]1[CH2:39][CH2:40][CH2:41][CH2:42]1>>[CH2:16]([CH3:17])[O:18][C:19]([CH:20]([c:21]1[cH:22][cH:23][n:24][cH:25][cH:26]1)[CH2:36][c:32]1[cH:31][n:30][c:29]([Cl:28])[n:34][c:33]1[Cl:35])=[O:27]
