Sodium ion → 5-chloro-1-{3-[4-(5-chloro-1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)-1-piperidinyl]propyl}-1,3-dihydro-2H-benzimidazol-2-one

HRID 959835

Reaction equation

HRID 959835 reaction equation
[CH3:1][S:2]([OH:3])(=[O:4])=[O:5].[CH3:44][N:45]([CH3:46])[CH:47]=[O:48].[Cl:21][c:22]1[cH:23][c:24]2[c:25]([n:26]([CH:30]3[CH2:31][CH2:32][NH:33][CH2:34][CH2:35]3)[c:27](=[O:29])[nH:28]2)[cH:36][cH:37]1.[Cl:6][c:7]1[cH:8][c:9]2[c:10]([n:11]([CH2:15][CH2:16][CH2:17][OH:18])[c:12](=[O:14])[nH:13]2)[cH:19][cH:20]1.[Na+:38].[Na+:39].[O-:40][C:41](=[O:42])[O-:43]>>[Cl:6][c:7]1[cH:8][c:9]2[c:10]([n:11]([CH2:15][CH2:16][CH2:17][N:33]3[CH2:32][CH2:31][CH:30]([n:26]4[c:25]5[c:24]([cH:23][c:22]([Cl:21])[cH:37][cH:36]5)[nH:28][c:27]4=[O:29])[CH2:35][CH2:34]3)[c:12](=[O:14])[nH:13]2)[cH:19][cH:20]1

Participants

7

Reactant 6

HCID 923Sodium ion2×HCID 6228DimethylformamideHCID 6395Methanesulfonic AcidHCID 19660Carbonate IonHCID 1046075-Chloro-1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-oneHCID 30173585-chloro-1,3-dihydro-1-(3-hydroxypropyl)-2H-benzimidazol-2-one

Product 1

HCID 203855425-chloro-1-{3-[4-(5-chloro-1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)-1-piperidinyl]propyl}-1,3-dihydro-2H-benzimidazol-2-one

Sources & evidence

ORD record
ord-3f3844cd182a4700b56457cabdcd0a14
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Linked notes

Loading…