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Hydrochloric Acid → 5-(Aminomethyl)-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine

HRID 961225
Notes
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Reaction equation

HRID 961225 reaction equation
[BH3:22].[CH2:25]1[O:26][CH2:27][CH2:28][CH2:29]1.[CH3:30][OH:31].[ClH:23].[NH2:1][c:2]1[n:3][cH:4][c:5]([C:6]#[N:7])[cH:8][c:9]1[O:10][CH:11]([CH3:12])[c:13]1[c:14]([Cl:21])[c:15]([F:20])[cH:16][cH:17][c:18]1[Cl:19].[OH2:24]>>[NH2:1][c:2]1[n:3][cH:4][c:5]([CH2:6][NH2:7])[cH:8][c:9]1[O:10][CH:11]([CH3:12])[c:13]1[c:14]([Cl:21])[c:15]([F:20])[cH:16][cH:17][c:18]1[Cl:19]
ParticipantsSources & evidenceReaction notes

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 887MethanolHCID 962WaterHCID 6331BoraneHCID 8028TetrahydrofuranHCID 211113376-Amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-nicotinonitrile

Product 1

HCID 211113225-(Aminomethyl)-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine

Sources & evidence

ORD record
ord-89d6bb78a0b24dce8267af35517f15d2
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D
DOI
10.1039/C8SC04228D

Reaction notes

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On this pageParticipantsSources & evidenceReaction notes