→ Ethyl 4-(3,4-dimethoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

HRID 962309Notes

Reaction equation

HRID 962309 reaction equation
CCO.CCOC(=O)CC(C)=O.COc1ccc(C=O)cc1OC.NC(N)=O.O.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Yb+3]>>CCOC(=O)C1=C(C)NC(=O)NC1c1ccc(OC)c(OC)c1

Participants

6

Reactant 0

No Reactant data yet.

Product 1

HCID 625994Ethyl 4-(3,4-dimethoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylateYield 52%

Reagents, catalysts & solvents 5

HCID 702EthanolOther2×HCID 1176UreaOtherHCID 8419VeratraldehydeOtherHCID 8868Ethyl AcetoacetateOtherHCID 45075687Ytterbium(3+) trifluoromethanesulfonate--water (1/3/1)Other

Conditions

Temperature
120 °C

Workup

  1. waitNo procedure recorded
  2. filtrationKeep solid
  3. washNo procedure recorded
  4. dry in vacuumNo procedure recorded

Sources & evidence

ORD record
ord-81cca4cbe5874959bbef910f6510e196
Source dataset
Microwave-assisted Biginelli Condensation Dataset
Original link
View source

Reaction notes

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