→ 4-(4-Bromophenyl)-N~5~,N~5~-diethyl-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide

HRID 962345

Reaction equation

HRID 962345 reaction equation
CC(=O)O.CCN(CC)C(=O)CC(C)=O.CCO.NC(N)=O.O.O=Cc1ccc(Br)cc1.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Yb+3]>>CCN(CC)C(=O)C1=C(C)NC(=O)NC1c1ccc(Br)cc1

Participants

7

Reactant 0

No Reactant data yet.

Product 1

HCID 38984074-(4-Bromophenyl)-N~5~,N~5~-diethyl-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamideYield 61%

Reagents, catalysts & solvents 6

HCID 176Acetic AcidOtherHCID 702EthanolOtherHCID 1176UreaOtherHCID 16699Acetoacetamide, N,N-diethyl-OtherHCID 707414-BromobenzaldehydeOtherHCID 45075687Ytterbium(3+) trifluoromethanesulfonate--water (1/3/1)Other

Conditions

Temperature
120 °C

Workup

  1. waitNo procedure recorded
  2. additionNo procedure recorded
  3. waitNo procedure recorded
  4. filtrationKeep solid
  5. washNo procedure recorded
  6. dry in vacuumNo procedure recorded

Sources & evidence

ORD record
ord-125faeae0b97472cb3968dc0db0efffe
Source dataset
Microwave-assisted Biginelli Condensation Dataset
Original link
View source

Linked notes

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