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Dicyclohexylcarbodiimide → 3-[2-{2-(2-Oxopropyl)-1-cyclohexenyl}-3-oxo-2,3-dihydropyridazin-6-yl]-2-phenylpyrazolo[1,5-a]pyridine

HRID 965365
Notes
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Reaction equation

HRID 965365 reaction equation
[C:1]([CH2:4][C:5]1[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=1[N:11]1[C:16](=[O:17])[CH:15]=[CH:14][C:13]([C:18]2[C:19]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[N:20][N:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=23)=[N:12]1)(O)=[O:2].[CH3:33]C1(C)OC(=O)CC(=O)O1.C1(N=C=NC2CCCCC2)CCCCC1>ClCCl.CN(C)C1C=CN=CC=1.C(O)(=O)C.O>[O:2]=[C:1]([CH3:33])[CH2:4][C:5]1[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=1[N:11]1[C:16](=[O:17])[CH:15]=[CH:14][C:13]([C:18]2[C:19]([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)=[N:20][N:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=23)=[N:12]1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

8

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 162492,2-Dimethyl-1,3-dioxane-4,6-dioneHCID 9910335FR-166124

Product 1

HCID 226292313-[2-{2-(2-Oxopropyl)-1-cyclohexenyl}-3-oxo-2,3-dihydropyridazin-6-yl]-2-phenylpyrazolo[1,5-a]pyridineYield 25.1%

Reagents, catalysts & solvents 4

HCID 14284
4-(Dimethylamino)pyridine
Catalyst
HCID 176Acetic AcidSolvent
HCID 962WaterSolvent
HCID 6344DichloromethaneSolvent

Procedure

To a solution of 3-[2-(2-carboxymethyl-1-cyclohexenyl)-3-oxo-2,3-dihydropyridazin-6-yl]-2-phenylpyrazolo[1,5-a]pyridine (2 g) in dichloromethane (20 ml) was added in turn 2,2-dimethyl-1,3-dioxane-4,6-dione (750 mg), 1,3-dicyclohexylcarbodiimide (1.1 g) and 4-dimethylaminopyridine (720 mg) at 0° C. A reaction mixture was allowed to warm to ambient temperature and stirred for overnight. Precipitate was removed by filtration, and mother liquor was washed with 1N-aqueous hydrochloric acid and dried over magnesium sulfate. Evaporation of the solvent gave a residue, which was dissolved in a mixture of acetic acid (15 ml) and water (15 ml), and which was refluxed for 10 hours. A reaction mixture was extracted with ethyl acetate (200 ml) and organic layer was separated, which was neutralized with saturated sodium hydrogen carbonate in water. Organic phase was separated, washed in turn with saturated sodium hydrogen carbonate in water (50 ml) and brine (50 ml×2), and dried over magnesium sulfate. Evaporation of the solvent gave a residue, which was chromatographed on silica gel (100 g) eluting in turn with 33%, 50%, 80% ethyl acetate in n-hexane and ethyl acetate to give 3-[2-{2-(2-oxopropyl)-1-cyclohexenyl}-3-oxo-2,3-dihydropyridazin-6-yl]-2-phenylpyrazolo[1,5-a]pyridine (0.5 g).

Workup

  1. customPrecipitate was removed by filtration, and mother liquor
  2. washwas washed with 1N-aqueous hydrochloric acid
  3. dry with materialdried over magnesium sulfate
  4. customEvaporation of the solvent
  5. customgave a residue, which
  6. temperaturewas refluxed for 10 hours
  7. extractionA reaction mixture was extracted with ethyl acetate (200 ml) and organic layer
  8. customwas separated
  9. customOrganic phase was separated
  10. washwashed in turn with saturated sodium hydrogen carbonate in water (50 ml) and brine (50 ml×2)
  11. dry with materialdried over magnesium sulfate
  12. customEvaporation of the solvent
  13. customgave a residue, which
  14. customwas chromatographed on silica gel (100 g)
  15. washeluting in turn with 33%, 50%, 80% ethyl acetate in n-hexane and ethyl acetate

Sources & evidence

ORD record
ord-227b203e16b947b6ad4b89cd5247d8b0
Source dataset
uspto-grants-1998_06
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05773530

Reaction notes

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