Reaction equation
[Cl:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([CH2:9][OH:10])[N:3]=1.C([O-])(O)=O.[Na+].[I:16]I.OS([O-])(=O)=O.[Na+]>O>[Cl:1][C:2]1[C:7]([OH:8])=[C:6]([I:16])[CH:5]=[C:4]([CH2:9][OH:10])[N:3]=1Participants
Procedure
2-Chloro-6-(hydroxymethyl)-3-pyridinol (11.6 g, 72.7 mmol) and NaHCO3 (18.3 g, 218 mmol) are dissolved in 200 ml water in a flask. The mixture is stirred until homogeneous, is cooled in an ice bath, is treated with iodine (19.4 g, 76.3 mmol), and is stirred over 60 h at rt as the cooling bath expired. The pH of the mixture is adjusted to 3 with 2N NaHSO4, and the mixture is extracted with 4×50 ml EtOAc. The combined organic layer is dried (MgSO4) and is concentrated in vacuo to a yellow solid. The crude solid is washed with EtOAc to provide 12.9 g (62%) of 2-chloro-6-(hydroxymethyl)-4-iodo-3-pyridinol as an off-white solid. The filtrate is concentrated to a small volume and is chromatographed over 250 g SiO2 (230-400 mesh) eluting with EtOAc/CH2Cl2/hexane/acetic acid 2.5:4.5:4:0.1. The appropriate fractions are combined and concentrated to afford an additional 2.4 g (12%) of pure 2-chloro-6-(hydroxymethyl)-4-iodo-3-pyridinol. MS for C6H5ClINO2, m/z: 285 (M)+.
Workup
- temperatureis cooled in an ice bath
- stirringis stirred over 60 h at rt as the cooling bath
- extractionthe mixture is extracted with 4×50 ml EtOAc
- dry with materialThe combined organic layer is dried (MgSO4)
- concentrationis concentrated in vacuo to a yellow solid
- washThe crude solid is washed with EtOAc
Sources & evidence
- ORD record
- ord-f8b9977570e745fda8dcc06868bd11cf
- Source dataset
- uspto-grants-2005_10
- Patent number
- US06951868B2
Linked notes
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