Lithium hydroxide, monohydrate → 3-[2-(2,4-Dichloro-phenyl)-acetylamino]-4-methoxy-benzoic Acid

HRID 967452

Reaction equation

HRID 967452 reaction equation
C[O:2][C:3](=[O:24])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[C:6]([NH:12][C:13](=[O:23])[CH2:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=2[Cl:22])[CH:5]=1.O.[OH-].[Li+]>CO.O.Cl>[Cl:22][C:16]1[CH:17]=[C:18]([Cl:21])[CH:19]=[CH:20][C:15]=1[CH2:14][C:13]([NH:12][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[O:10][CH3:11])[C:3]([OH:24])=[O:2])=[O:23]

Participants

5

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 696522653-[2-(2,4-Dichloro-phenyl)-acetylamino]-4-methoxy-benzoic acid methyl ester

Product 1

HCID 220524883-[2-(2,4-Dichloro-phenyl)-acetylamino]-4-methoxy-benzoic Acid

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 22242641Methanol--water (1/1)Solvent

Procedure

To a solution of 400 mg 3-[2-(2,4-Dichloro-phenyl)-acetylamino]-4-methoxy-benzoic acid methyl ester in 5 ml MeOH/H2O 2:1 56 mg lithium hydroxide monohydrate were added and the mixture was stirred over night. The suspension was diluted with 5 ml concentrated HCl to precipitate the acid. After filtration the filter cake was washed twice with water and then dried to yield the acid as a white powder.

Workup

  1. customto precipitate the acid
  2. filtrationAfter filtration the filter cake
  3. washwas washed twice with water
  4. customdried

Sources & evidence

ORD record
ord-40b18fa587c940169e6e5483d895e1b1
Source dataset
uspto-grants-2005_10
Patent number
US06953857B2

Linked notes

Loading…