Oxalyl chloride → 3-Morpholinobenzoyl chloride
Reaction equation
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[O:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:14]=C([CH:19]=[CH:20][CH:21]=2)C(O)=O)[CH2:9][CH2:8]1>C(Cl)Cl.CN(C=O)C>[O:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:14]=[C:1]([CH:19]=[CH:20][CH:21]=2)[C:2]([Cl:4])=[O:3])[CH2:9][CH2:8]1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
Oxalyl chloride (0.14 ml) was added to a solution of 3-morpholinobenzoic acid (0.28 g) in methylene chloride (10 ml) which contained DMF (2 drops). The reaction mixture was stirred for 18 hours at ambient temperature. The mixture was evaporated and azeotroped with toluene to give 3-morpholinobenzoyl chloride (0.3 g); Mass M+H 222.
Workup
- customThe mixture was evaporated
- customazeotroped with toluene
Sources & evidence
- ORD record
- ord-5e02ade00c204f609630fe6d0e5dcf6c
- Source dataset
- uspto-grants-2005_10
- Patent number
- US06956037B2
Reaction notes
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