Benzene → HCID 21312565, compound

HRID 971921

Reaction equation

[CH2:1]([C:3]1([CH2:12][CH3:13])[C:8](=[O:9])[NH:7][C:6](=[O:10])[NH:5][C:4]1=[O:11])[CH3:2].Cl[CH2:15][CH2:16][CH2:17][C:18]([O:20][CH3:21])=[O:19].[C:22](=[O:25])([O-])[O-:23].[K+].[K+].[CH:28]1[CH:33]=CC=C[CH:29]=1.[CH3:34]N(C)C=O>>[CH3:21][O:20][C:18]([CH2:17][CH2:16][CH2:15][N:7]1[C:8](=[O:9])[C:3]([CH2:1][CH3:2])([CH2:12][CH3:13])[C:4](=[O:11])[N:5]([CH2:29][CH2:28][CH2:33][C:22]([O:23][CH3:34])=[O:25])[C:6]1=[O:10])=[O:19]

Participants

Reactant 5

HCID 241Benzene

HCID 2294Barbital

HCID 6228Dimethylformamide

HCID 11430Potassium Carbonate

HCID 76612Butanoic acid, 4-chloro-, methyl ester

Product 1

HCID 21312565HCID 21312565, compound

Procedure

18.4 g (0.1 mol) of 5,5-diethylbarbituric acid are reacted with 28.7 g (0.21 mol) of methyl γ-chlorobutyrate according to Example 1. 15.2 g (0.11 mol) of potassium carbonate powder are used as the acid acceptor and 100 ml of benzene and 100 ml of dimethylformamide are used as the solvent. The reaction is carried out exactly according to Example 1 and likewise worked up. In this manner, 38.3 g (99.7% of theory) of a clear, slightly discoloured viscous product are obtained.

Workup

customIn this manner, 38.3 g (99.7% of theory) of a clear, slightly discoloured viscous product are obtained

Sources & evidence

ORD record: ord-38018ddc63f14eb8b330d469b9e561c9
Source dataset: uspto-grants-1979_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04161603

Linked notes

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