Hydrochloric Acid → 4-(4-Nitrophthalimido)-1-(2-phenylethyl)piperidine

HRID 972820

Reaction equation

HRID 972820 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[O:12])[O:10][C:8](=O)[C:7]2=[CH:13][CH:14]=1)([O-:3])=[O:2].[NH2:15][CH:16]1[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:18][CH2:17]1.Cl>>[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[O:12])[N:15]([CH:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH2:18][CH2:17]3)[C:8](=[O:10])[C:7]2=[CH:13][CH:14]=1)([O-:3])=[O:2]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 2309764-Nitrophthalic acid anhydrideHCID 107287881-(2-Phenylethyl)piperidin-4-amine

Product 1

HCID 214055654-(4-Nitrophthalimido)-1-(2-phenylethyl)piperidine

Procedure

9.66 Grams of 4-nitrophthalic anhydride and 10.11 grams of 4-amino-1-(2-phenylethyl)piperidine were reacted in a similar manner to that described in Example 12 to give 10.51 grams of the title compound as the monohydrochloride.

Sources & evidence

ORD record
ord-56fca257a7c7457e998c04bc4a559caa
Source dataset
uspto-grants-1977_10
Patent number
US04053615

Linked notes

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