Dimethylformamide → 5-[4-(2-Fluoro-3-methyl-benzyl)-piperazin-1-yl]-quinazoline-2,4-diamine

HRID 97372

Reaction equation

HRID 97372 reaction equation
[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH3:7].[CH3:36][N:37]([CH3:38])[CH:39]=[O:40].[F:26][c:27]1[c:28]([CH2:29][Br:30])[cH:31][cH:32][cH:33][c:34]1[CH3:35].[N:8]1([c:14]2[c:15]3[c:16]([NH2:25])[n:17][c:18]([NH2:24])[n:19][c:20]3[cH:21][cH:22][cH:23]2)[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1>>[N:8]1([c:14]2[c:15]3[c:16]([NH2:25])[n:17][c:18]([NH2:24])[n:19][c:20]3[cH:21][cH:22][cH:23]2)[CH2:9][CH2:10][N:11]([CH2:29][c:28]2[c:27]([F:26])[c:34]([CH3:35])[cH:33][cH:32][cH:31]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 519062Benzene, 1-(bromomethyl)-2-fluoro-3-methyl-HCID 180713185-Piperazin-1-yl-quinazoline-2,4-diamine

Product 1

HCID 250048715-[4-(2-Fluoro-3-methyl-benzyl)-piperazin-1-yl]-quinazoline-2,4-diamine

Sources & evidence

ORD record
ord-e5afabae0f214cbdae26dbb8a4fa4d79
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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