Sodium Chloride → HCID 15667144, compound

HRID 973770

Reaction equation

HRID 973770 reaction equation
[Na].[CH3:2][C@@H:3]1[C@@H:21]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:6]2[C:7](Cl)=[N:8][C:9]3[N:13]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[N:12]=[CH:11][C:10]=3[C:5]2=[N:4]1.[O-:28][CH2:29][CH2:30][CH3:31].[Na+].[Cl-]>C(O)CC>[CH3:2][C@@H:3]1[C@@H:21]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:6]2[C:7]([O:28][CH2:29][CH2:30][CH3:31])=[N:8][C:9]3[N:13]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[N:12]=[CH:11][C:10]=3[C:5]2=[N:4]1

Participants

6

Reactant 4

HCID 5234Sodium ChlorideHCID 5360545SodiumHCID 125435151-Propanol, ion(1-)HCID 15667140HCID 15667140, compound

Product 1

HCID 15667144HCID 15667144, compound

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent2×

Procedure

51 mg sodium was dissolved in 5 ml n-propanol. 670 mg of the above product (2R-trans)-2,7-dihydro-2-methyl-3,7-diphenyl-5-chloro-3H-imidazo[1,2-c]pyrazolo[4,3-e]pyrimidine dissolved in 15 ml n-propanol was added to the propoxide solution with stirring. After 1 hour the reaction was poured into 200 ml saturated NaCl and the extracts were dried over MgSO4, filtered and concentrated to yield an oil which was purified by radial chromatography (30-50-70-90% ethanol/ hexane, 2 mm plate) to yield 600 mg of (2R-trans)-2,7-dihydro-2-methyl-3,7-diphenyl-5-propoxy-3H-imidazo[1,2-c]pyrazolo[4,3-e]pyrimidine.

Workup

  1. dry with materialthe extracts were dried over MgSO4
  2. filtrationfiltered
  3. concentrationconcentrated
  4. customto yield an oil which
  5. customwas purified by radial chromatography (30-50-70-90% ethanol/ hexane, 2 mm plate)

Sources & evidence

ORD record
ord-977b111411004781a6cca546565ac9e0
Source dataset
uspto-grants-1991_11
Patent number
US05064947

Linked notes

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