Aniline → 2-Phenylamino-6-trifluoromethyl-nicotinic acid

HRID 97484

Reaction equation

HRID 97484 reaction equation
[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[CH3:15][SiH:16]([CH3:17])[N:18]([CH3:19])[Si:20]([CH3:21])([CH3:22])[CH3:23].[CH3:37][CH2:38][O:39][C:40](=[O:41])[CH3:42].[Cl:1][c:2]1[c:3]([C:4](=[O:5])[OH:6])[cH:7][cH:8][c:9]([C:11]([F:12])([F:13])[F:14])[n:10]1.[Li:24].[NH2:25][c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1>>[c:2]1([NH:25][c:26]2[cH:27][cH:28][cH:29][cH:30][cH:31]2)[c:3]([C:4](=[O:5])[OH:6])[cH:7][cH:8][c:9]([C:11]([F:12])([F:13])[F:14])[n:10]1

Participants

7

Reactant 6

HCID 6115AnilineHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 589711N-dimethylsilyl-N-trimethylsilylmethanamineHCID 27782102-Chloro-6-(trifluoromethyl)nicotinic acidHCID 3028194Lithium

Product 1

HCID 708171352-Phenylamino-6-trifluoromethyl-nicotinic acid

Sources & evidence

ORD record
ord-ef7a33c3a542450095c75c88ccddd26c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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