3-Nitrobenzenesulfonic acid → 6-[4-(Imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone

HRID 979284

Reaction equation

HRID 979284 reaction equation
[N:1]1([CH2:6][C:7]2[CH:8]=[C:9]([C:12]3[CH2:13][CH2:14][C:15](=[O:18])[NH:16][N:17]=3)[S:10][CH:11]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[Na].[N+](C1C=C(S(O)(=O)=O)C=CC=1)([O-])=O.[OH-].[Na+]>O.C(O)(=O)C>[N:1]1([CH2:6][C:7]2[CH:8]=[C:9]([C:12]3[CH:13]=[CH:14][C:15](=[O:18])[NH:16][N:17]=3)[S:10][CH:11]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

7

Reactant 4

HCID 73873-Nitrobenzenesulfonic acidHCID 14798Sodium HydroxideHCID 5360545SodiumHCID 133187044.5-dihydro-6-[4-(imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone

Product 1

HCID 133702466-[4-(Imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

Analoguous to Example 4, the reaction is carried out with 3 g of 4.5-dihydro-6-[4-(imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone (prepared analoguous to Example 3, m.p. 178° to 179° C.), 2.9 g of the sodium salt of 3-nitrobenzenesulfonic acid and 2 g of sodium hydroxide in 40 ml of water. The reaction mixture is neutralized by the addition of 2.5 ml of acetic acid.

Sources & evidence

ORD record
ord-c3b3db63f4814e29a542ad232f754e4d
Source dataset
uspto-grants-1987_05
Patent number
US04667033

Linked notes

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