Nicotinamide → L-Isoleucine

HRID 980496

Reaction equation

HRID 980496 reaction equation
[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH:4]([CH3:6])C.N[C@H:11](C(O)=O)CCCCN.N[C@H](C(O)=O)CCSC.N[C@H](C(O)=O)CC1C=CC=CC=1.N[C@H](C(O)=O)[C@@H](C)O.N[C@H](C(O)=O)C(C)C.C(SSC[C@H](N)C(O)=O)[C@H](N)C(O)=O.CC1[N+](CC2C=NC(C)=NC=2N)=CSC=1CCO.Cl.[Cl-].C1C=NC=C(C(N)=O)C=1.CC1N=CC(CO)=C(CO)C=1O.Cl.OC1[C@@H]([C@@H](O)CO)OC(=O)C=1O>CC1C(C)=CC2N([C@H]3O[C@H](CO)[C@@H](OP(O[C@@H](CNC(CC[C@@]4(C)C5=N[C@@H]([C@]6(C)[N-]C(=C(C)C7[C@](CC(N)=O)(C)[C@H](CCC(N)=O)C(=CC8C(C)(C)[C@H](CCC(N)=O)C(=C5C)N=8)N=7)[C@@H](CCC(N)=O)[C@@]6(CC(N)=O)C)[C@@H]4CC(N)=O)=O)C)([O-])=O)[C@H]3O)C=NC=2C=1.[C-]#N.[Co+3]>[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[C@H:3]([CH2:4][CH3:6])[CH3:11]

Participants

13

Reactant 11

HCID 936NicotinamideHCID 5962L-LysineHCID 6019Pyridoxine HydrochlorideHCID 6106L-LeucineHCID 6137L-MethionineHCID 6140L-PhenylalanineHCID 6202Thiamine HydrochlorideHCID 6287L-ValineHCID 6288L-ThreonineHCID 67678(-)-CystineHCID 54670067L-Ascorbic Acid

Product 1

HCID 6306L-Isoleucine

Reagents, catalysts & solvents 1

HCID 5311498Dtxcid5024346Catalyst

Procedure

L-leucine (2.4 g); L-lysine (1.5 g); L-methionine (1.4 g); L-phenylalanine (2.0 g); L-threonine (1.4 g); L-valine (1.5 g); L-cystine (0.2 g); vitamin A 5000 I.U.; vitamin B1 (1.6 mg); vitamin B12 (2.5 mg); vitamin PP (18 mg); vitamin B6 (2.4 mg) and vitamin C (100 g).

Sources & evidence

ORD record
ord-220cd93ff41c4d30ae9393dadc683389
Source dataset
uspto-grants-1987_01
Patent number
US04638013

Linked notes

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