2-Amino-5-chloropyridine → N-(5-Chloropyridin-2-yl)-4-methoxycarbonyl-2-nitrobenzamide

HRID 988674

Reaction equation

HRID 988674 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=O)=[C:7]([N+:14]([O-:16])=[O:15])[CH:6]=1)=[O:4].[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][N:19]=1>>[Cl:24][C:21]1[CH:22]=[CH:23][C:18]([NH:17][C:9](=[O:11])[C:8]2[CH:12]=[CH:13][C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:6][C:7]=2[N+:14]([O-:16])=[O:15])=[N:19][CH:20]=1

Participants

3

Reactant 2

HCID 661742-Amino-5-chloropyridineHCID 219064744-(Methoxycarbonyl)-2-nitrobenzoic acid

Product 1

HCID 21906271N-(5-Chloropyridin-2-yl)-4-methoxycarbonyl-2-nitrobenzamideYield 74%

Procedure

Using a similar procedure to that described in Example 1-A, 4-methoxycarbonyl-2-nitrobenzoic acid (1.87 g, 8.31 mmol) and 2-amino-5-chloropyridine (1.16 g, 9.14 mmol) afforded 2.05 g (74%) of the title compound.

Sources & evidence

ORD record
ord-2f82940ef3da416d9419900ed14144db
Source dataset
uspto-grants-2003_10
Patent number
US06635657B1

Linked notes

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