Methyl p-toluenesulfonate → 2-Fluoro-1-methylpyridinium p-toluenesulfonate

HRID 989060

Reaction equation

HRID 989060 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:8][C:9]1[CH:14]=[CH:13][C:12]([S:15]([O:18]C)(=[O:17])=[O:16])=[CH:11][CH:10]=1>>[CH3:8][C:9]1[CH:10]=[CH:11][C:12]([S:15]([O-:18])(=[O:17])=[O:16])=[CH:13][CH:14]=1.[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N+:3]=1[CH3:8]

Participants

3

Reactant 2

HCID 6645Methyl p-toluenesulfonateHCID 97462-Fluoropyridine

Product 1

HCID 1716312-Fluoro-1-methylpyridinium p-toluenesulfonate

Conditions

Temperature
70 °C

Procedure

10 mmol of 2-fluoropyridine and 10 mmol of methyl 4-methylbenzenesulphonate are mixed in a 50 ml round-bottomed flask and stirred for 6 hours at 70° C. under a nitrogen atmosphere. The salt obtained in the form of a white solid is used without additional purification in the following step.

Workup

  1. customThe salt obtained in the form of a white solid
  2. customis used without additional purification in the following step

Sources & evidence

ORD record
ord-69e889f052d14059a99a12de8bf46d29
Source dataset
uspto-grants-2003_10
Patent number
US06638946B2

Linked notes

Loading…