Triethylamine → 1-Ethyl-heptyl Methanesulphonate

HRID 989729

Reaction equation

HRID 989729 reaction equation
[CH3:1][CH2:2][CH:3]([OH:10])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].C(N(CC)CC)C.[S:18](Cl)([CH3:21])(=[O:20])=[O:19]>ClCCl>[CH3:21][S:18]([O:10][CH:3]([CH2:2][CH3:1])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])(=[O:20])=[O:19]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 122163-NonanolHCID 31297Methanesulfonyl chloride

Product 1

HCID 178887511-Ethyl-heptyl Methanesulphonate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

20 g (138.6 mmol) of 3-nonanol and 15.43 g of triethylamine are dissolved in 150 ml of dichloromethane and admixed dropwise with 17.47 g (152.5 mmol) of mesyl chloride. The mixture is stirred at room temperature for 4 hours. The organic phase is extracted twice with water and dried over sodium sulphate and the solvent is removed under reduced pressure. This gives 30.7 g (95%) of a yellow liquid.

Workup

  1. extractionThe organic phase is extracted twice with water
  2. dry with materialdried over sodium sulphate
  3. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-7037ee5a11594c51a1423eb7fc22d7f3
Source dataset
uspto-grants-2002_10
Patent number
US06458796B1

Linked notes

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