2-ヘキサノン

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:

Use alcohol-resistant foam, powder, carbon dioxide. In case of fire: keep cylinder cool by spraying with water.

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

(General first aid procedures)

Biological Exposure Indices (BEI) [ACGIH] - 2,5-Hexanedione (free) in urine = 0.4 mg/L end of shift at end of workweek;

5.0 [ppm]

If material is on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.

Water may be ineffective. Alcohol foam.

MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMPOSE INTO TOXIC COMPONENTS ... SHOULD BE STORED IN A COOL WELL VENTILATED PLACE, OUT OF THE DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, AND SHOULD BE PERIODICALLY INSPECTED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED ...

Environmental considerations -- land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bangs, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents.

Environmental considerations -- water spill: Use natural barriers or oil spill control booms to limit spill travel. Remove trapped material with suction hoses.

Environmental considerations -- air spill: Apply water spray or mist to knock down vapors.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

2-Hexanone was shown to undergo rapid (less than eight weeks) anaerobic biodegradation utilizing an anaerobic digester sludge inoculum.

The following wastewater treatment technologies have been investigated for 2-hexanone: Activated carbon.

Spray into the furnace. Incineration will become easier by mixing with a more flammable solvent. Recommendable method: Incineration.

Personal protection: self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to disperse vapors and dilute standing pools of liquid.

Personnel protection: Avoid breathing vapors. Keep upwind. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. Avoid bodily contact with the material.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

The worker should immediately wash the skin when it becomes contaminated.

For more Preventive Measures (Complete) data for 2-HEXANONE (6 total), please visit the HSDB record page.

Enhancement of MnBK neurotoxicity by MEK (methyl ethyl ketone) was reported ... Exposure of 225 ppm MnBK, 1125 ppm MEK, and 225 ppm MnBK plus 1125 ppm MEK in rats /indicated/ that the addition of high levels of MEK to a neurotoxic dose of MnBK shortened the onset of paralysis from 66 to 25 days ...

Inhalation of MEK (methyl ethyl ketone)/MnBK shortened hexobarbital sleeping time and increased in vitro production of n-aminophenol, formaldehyde, n-aminobenzoate, and sulfanilamide by rat hepatocyte microsomes ... Phenobarbital, also a microsomal inducer, protects against MnBK neurotoxicity ... Trans-1,2-dichloroethylene, an inhibitor of P450 2El, increased the exhaled MnBK concentration in rats not exposed to MnBK, presumably by decreasing the metabolism of endogeneous MnBK.

While MnBK itself does produce liver or kidney toxicity, exposure to MnBK is reported to enhance the activity of materials that are hepatotoxic or nephrotoxic. Prior exposure to an oral dose of MnBK followed by chloroform has been reported to enhance the toxicity, resulting in increased liver enzyme and urea nitrogen levels in the plasma, altered bile flow, and degenerative changes in hepatic and renal tissue. These effects are postulated to be due to alteration in P450 levels by MnBK. MnBK exposure may also alter the activity of other enzyme systems ... the inhibition of alcohol dehydrogenase by MnbK results in slower elimination of ethanol from the blood and prolongation of ethanol-induced loss of the righting reflex.

Body Weight, Neurological (Nervous System), Reproductive (Producing Children)

Nervous

Eyes, skin, respiratory system, central nervous system, peripheral nervous system

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 134(SRC), determined from a log Kow of 1.38(2) and a regression-derived equation(3), indicates that 2-hexanone is expected to have high mobility in soil(SRC). Volatilization of 2-hexanone from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 9.3X10-5 atm-cu m/mole(SRC), derived from its vapor pressure of 11.6 mm Hg(4) and water solubility of 17,200 mg/L(5). Volatilization from dry soil surfaces is expected(SRC) based upon the vapor pressure of this compound(4). Theoretical 5-day BOD results of 59%(6) and 61.4%(7) degradation indicate that biodegradation may be an important fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 134(SRC), determined from a log Kow of 1.38(2) and a regression-derived equation(3), indicates that 2-hexanone is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 9.3X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 11.6 mm Hg(4), and water solubility, 17,200 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 7 and 164 hours, respectively(SRC). According to a classification scheme(6), an estimated BCF 2(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Theoretical 5-day BOD results of 59%(8) and 61.4%(9) degradation indicate that biodegradation may be an important fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-hexanone, which has a vapor pressure of 11.6 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2-hexanone is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 2 days(3).

2-Hexanone has been identified, not quantified as a component of the aromatic fraction of blue cheese(1) and Beaufort (Gruyere) cheese(2). 2-Hexanone has been identified, not quantified as a component of raw chicken breast muscle(3). 2-Hexanone has been identified, not quantified as a volatile component of roasted filberts(4), nectarines(5), mutton(6), chicken(6), beef(6,7) and cognac(8). 2-Hexanone has been detected in white bread, toasted oats and uncured beef (0.38 mg/kg)(6). 2-Hexanone has been detected in canned cream (1 ppb), canned kernel (2 ppb), frozen kernel (<5 ppb) and fresh kernel (<1 ppb) corn products(9).

The substance can be absorbed into the body by inhalation and through the skin.

inhalation, skin absorption, ingestion, skin and/or eye contact

Oral (L176); inhalation (L176) ;dermal (L176)

2-Hexanone's toxicity is believed to be caused by covalent binding of its metabolites, especially 2,5-hexanedione, with axonal components of nerve tissue and inhibition of enzymes associated with the production of energy in this tissue. 2-Hexanone and 2,5-hexanedione may also inhibit sulfhydryl-dependent enzymes such as fructose-6-phosphate kinase and glyceraldehyde-3-phosphate dehydrogenase, as well as certain creatine kinases and adenylate kinases, impairing energy metabolism and subsequently resulting in axon deterioration. In addition, 2,5-hexanedione can covalently cross-links neurofilaments, causing large axonal swellings. (L176, A124, A125)

Cough. Drowsiness. Headache. Nausea. Sore throat.

MAY BE ABSORBED! Dry skin.

Redness. Pain. Blurred vision.

Abdominal pain. Diarrhoea. Sore throat. Further see Inhalation.

irritation eyes, nose; peripheral neuropathy: lassitude (weakness, exhaustion), paresthesia; dermatitis; headache, drowsiness

Chronic 2-hexanone exposure causes weakness, numbness, tingling in the skin of the hands and feet, irritation to the lungs, and narcosis. (L176)

No longer used in the USA, but used in the past in organic synthesis and as a solvent for inks, coatings, adhesives, oils, waxes, etc.; [CHEMINFO]

Not currently produced or used in the US; Production ceased in 1979; [ATSDR ToxProfile]

MnBK is a ketonic solvent used in a wide variety of materials, including paints, lacquers, ink thinners, nitrocellulose, glues, resins, oils, fats, and waxes, and in printing of plasticized fabric.

... It is a medium evaporating solvent for nitrocellulose acrylates, vinyl, and alkyd coatings.

2-Hexanone was used in the past in paint and paint thinner, to make other chemical substances, and to dissolve oils and waxes. Today it is formed as a waste product resulting from industrial activities such as wood pulping, coal gasification, and oil shale operations. (L176)

2-Hexanone can be made, in 75% yield, by reaction of acetyl chloride with butylmagnesium chloride.

MnBK can be produced by a reaction between acetic acid and ethylene under pressure with a catalyst.

GRADE: Technical

Commercial grades of MnBK vary in purity from 70 to 96%; the more dilute grades include predominantly methyl isobutyl ketone (MiBK).