2-Amino-2-methyl-1-propanol → 2-[[(1-Oxo-1,3-dihydroisobenzofuran-5-yl)carbonyl]amino]-2-methyl-1-propanol

HRID 23182

反応式

HRID 23182 の反応式
C(O[C:4]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[C:11](=[O:12])[O:10][CH2:9]2)=[O:5])C.[NH2:16][C:17]([CH3:21])([CH3:20])[CH2:18][OH:19]>C1(C)C=CC=CC=1>[OH:19][CH2:18][C:17]([NH:16][C:4]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[C:11](=[O:12])[O:10][CH2:9]2)=[O:5])([CH3:21])[CH3:20]

参加物

4

反応物 2

HCID 118072-Amino-2-methyl-1-propanolHCID 90088Ethyl 1,3-dihydro-1-oxoisobenzofuran-5-carboxylate

生成物 1

HCID 111960052-[[(1-Oxo-1,3-dihydroisobenzofuran-5-yl)carbonyl]amino]-2-methyl-1-propanol

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Method B): 5-Ethoxycarbonylphthalid (82 g, 0.4 mole) is added to a solution of 2-amino-2-methylpropan-1-ol (44.6 g. 0.5 mole) in toluene (100 ml). The mixture is heated to reflux temperature for 24 hours. Upon cooling the title compound is filtered off and recrystallised from hot toluene.

後処理

  1. temperatureThe mixture is heated
  2. temperatureto reflux temperature for 24 hours

出典と根拠

ORDレコード
ord-b1c7e6f305a2432c90684e7fd8d07359
出典データセット
uspto-grants-2005_02
特許番号
US06849749B2

関連ノート

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