Fentanyl Citrate

HCID 13810CAS 990-73-8

基本情報

標準SMILES: CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O
InChIKey: IVLVTNPOHDFFCJ-UHFFFAOYSA-N
分子式: C28H36N2O8
平均分子量: 528.6 g/mol
単同位体質量: 528.24716611

概要

Fentanyl citrate is the citric acid salt of fentanyl, comprising equimolar amounts of citric acid and fentanyl. A -opioid receptor agonist, it is a potent opioid analgesic used in the management of labour pain, postoperative pain, and chronic intractable cancer pain. It is also widely used as the analgesic component of balanced anaesthesia. It has a role as an opioid analgesic and a mu-opioid receptor agonist. It contains a fentanyl.

名称と識別子

優先名称: Fentanyl Citrate
IUPAC: 2-hydroxypropane-1,2,3-tricarboxylic acid;N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide

名称と別名

FENTANYL CITRATE990-73-8LeptanalOraletPhentanyl citrateActiqAbstralLazandaOnsolisInstanylFentanyl buccalMcN-JR-4263-49

名称をさらに表示

Fentanyl citrate ciiSUBLIMAZE PRESERVATIVE FREEMUN5LYG46HN-(1-Phenethyl-4-piperidyl)propionanilide citrateFENTANYL CITRATE PRESERVATIVE FREEKw-2246N-(1-Phenethyl-4-piperidyl)propionanilide dihydrogen citrateN-(1-Phenethyl-4-piperidinyl)propionanilide dihydrogen citrate

データベース識別子

CAS: 990-73-8
PubChem CID: 13810
DTXSID: DTXSID80243933
ChEMBL: CHEMBL688
ChEBI: CHEBI:31602
UNII: MUN5LYG46H
EC Number: 213-588-0

物性

構造計算による物性

極性表面積: 156 Å²
水素結合供与体数: 4
水素結合受容体数: 9
回転可能結合数: 11
重原子数: 38
形式電荷: 0
複雑度: 618

実験および物理化学的性質

Chemical ClassesOther Uses -> Pharmaceuticals

Human Drugs · 3 件

FDA approved drugs -> Active ingredient

EMA approved medicines: Human medicine

FDA approved drugs -> Active ingredient

Animal DrugsActive Ingredients (Fentanyl Citrate) -> FDA Greenbook

安全と法規制

GHS分類

GHS Classification · 4 件

Danger

H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]

P233, P260, P261, P262, P264, P270, P271, P272, P280, P284, P301+P316, P302+P352, P304+P340, P316, P320, P321, P330, P333+P317, P342+P316, P361+P364, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 68 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory InformationFentanyl citrate: HSNO Approval: HSR003800 Approved with controls

Other Safety InformationIMAP assessments - Propanamide, N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]-,2-hydroxy-1,2,3-propanetricarboxylate (1:1): Environment tier I assessment

Hazards Summary · 1 件

Fentanyl is a solid. It is a Schedule II controlled substance. Fentanyl citrate is a strong analgesic used preoperatively, during surgery, and in the immediate postoperative period for its analgesic action. . . . Introduced into clinical practice in the 1960s, the analgesic fentanyl is 100 times more potent than morphine. [HSDB] TLV Basis is CNS impairment and respiratory depression; [ACGIH TLVs and BEIs]

Hazard Classes and CategoriesAcute Tox. 2 (100%)

安全と保護具

Threshold Limit Values (TLV) · 2 件

0.00001, inhalable particulate matter (Surface Level = 1 ug/100cm2)

0.00002, inhalable particulate matter

毒性情報

Adverse EffectsACGIH Carcinogen - Not Classifiable.

化学と産業

薬理情報

FDA Pharmacological Classification · 2 件

FENTANYL CITRATE

Opioid Agonist [EPC]; Full Opioid Agonists [MoA]

MeSH Pharmacological Classification · 4 件

Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.

Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.

Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.

Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)