Mannitol → Fentanyl

HRID 8554

反応式

HRID 8554 の反応式
C(O)[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.[CH3:13][CH2:14][C:15]([N:17]([CH:24]1[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH2:26][CH2:25]1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)=[O:16].C(C(O)(C(O)=O)CC(O)=O)C(O)=O.COC([C@@H](NC([C@@H](N)CC(O)=O)=O)CC1C=CC=CC=1)=O>O>[CH3:13][CH2:14][C:15]([N:17]([CH:24]1[CH2:25][CH2:26][N:27]([CH2:30][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:28][CH2:29]1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)=[O:16]

参加物

5

反応物 3

HCID 6251MannitolHCID 13810Fentanyl CitrateHCID 134601Aspartame

生成物 1

HCID 3345Fentanyl

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

Gelatin (765 g) and mannitol (540 g) were dispersed in a portion of purified water (16 kg) by mixing thoroughly in the bowl of a vacuum mixer. The mix was then heated to 40° C.±2° C. and homogenised for ten minutes to allow complete dissolution of the solids. The mix was cooled down to room temperature (20–24° C.). When cooled, the fentanyl citrate (22.68 g), the aspartame (90 g), and mint flavour (90 g) were added sequentially to the mix. The mix was then homogenized to ensure complete dissolution of the solids. The remaining water (492 g) was added to the mixer and the bulk mix homogenized to ensure dissolution was complete.

後処理

  1. additionby mixing thoroughly in the bowl of a vacuum mixer
  2. temperatureThe mix was then heated to 40° C.±2° C.
  3. dissolutiondissolution of the solids
  4. temperatureWhen cooled
  5. stirringThe mix was then homogenized
  6. dissolutiondissolution of the solids
  7. additionthe bulk mix
  8. stirringhomogenized
  9. dissolutiondissolution

出典と根拠

ORDレコード
ord-7699baaddd76414b851d402dc61a2e83
出典データセット
uspto-grants-2006_08
特許番号
US07090866B2

関連ノート

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